Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze
Authors
Abstract:
Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior in mice. Methods: Male mice were intraperitoneally (i.p.) administrated sildenafil (1, 2, or 10 mg/kg), and the control group was given the vehicle 15 min before the plus-maze test. The number of entries into the open arms of the plus-maze, the time spent in the open arms, and the total numbers of entries into the arms were recorded. Results: The results indicated that compared to the control group, the sildenafil-treated mice spent more time in the open arms and had a greater number of entries into open arms. The total number of entries into the arms did not significantly differ between the sildenafil-treated groups and the control group. Discussion: Acute administration of sildenafil could have anxiolytic effects on male mice. This effect might be mediated in a time-dependent manner by the NO/ cGMP/PDE5 pathway.
similar resources
modulation of anxiety-like behavior in sildenafil citrate-treated mice placed in an elevated plus-maze
introduction: sildenafil, a phosphodiesterase-5 (pde5) inhibitor, may have various effects on the central nervous system via the nitric oxide (no)-cyclic guanosine monophosphate (cgmp) pathway. preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. this study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
full textEffect of inhalation alcoholic extract of Peganum harmala on induction of Anxiety like behavior in Elevated Plus-Maze
Based on the extensive application of Peganum harmala (P.h) seeds in the Asian traditional medicine, we tried to investigate its possible anxiety effect. Method: The effect of P.h. extract inhalation was evaluated in adult male rats using elevated plus-maze apparatus. The humidity of prepared ethanol extract was 37%. Animals in different groups (n=6) received 2, 4, 6, 12 or 18 gr/ml doses of...
full textAn Assessment of Changes in Open-Field and Elevated Plus-Maze Behavior Following Heat Stress in Rats
This paper presents the effect of high environmental heat on behavior of the male Charles Foster rats. Eighty rats were divided into three groups, subjected to (i) acute heat stress (ii) chronic heat stress and (iii) handling control group. Animals were exposed to the hot environment in a biological oxygen demand incubator at 38 ± 1ºC (relative humidity 45-50%) for four hours of continuous sing...
full texteffect of inhalation alcoholic extract of peganum harmala on induction of anxiety like behavior in elevated plus-maze
based on the extensive application of peganum harmala (p.h) seeds in the asian traditional medicine, we tried to investigate its possible anxiety effect. method: the effect of p.h. extract inhalation was evaluated in adult male rats using elevated plus-maze apparatus. the humidity of prepared ethanol extract was 37%. animals in different groups (n=6) received 2, 4, 6, 12 or 18 gr/ml doses of th...
full textElevated Plus Maze for Mice
Although the mouse genome is now completely sequenced, the functions of most of the genes expressed in the brain are not known. The influence of a given gene on a specific behavior can be determined by behavioral analysis of mutant mice. If a target gene is expressed in the brain, behavioral phenotype of the mutant mice could elucidate the genetic mechanism of normal behaviors. The elevated plu...
full textMy Resources
Journal title
volume 2 issue 4
pages 53- 57
publication date 2011-08
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023